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Current Scientific Interest: Dani Osman's research is focused on unraveling the intricate interactions between emerging tropical pathogens, their hosts, and the vectors that transmit them. A key area of interest is the study of host pathophysiology, where he explores defense mechanisms and, more critically, the alterations in metabolic pathways that may either exacerbate disease or reflect the body's efforts to combat infection. On the vector side, his research centers on the intestinal barrier, a crucial frontline defense against pathogenic invasion. This barrier is a dynamic interface where the vector can either hinder or facilitate pathogen transmission. By dissecting the processes that govern the integrity and function of the vector’s intestinal barrier, he aims to enhance our understanding of pathogen transmission dynamics, paving the way for innovative control strategies. To achieve these objectives, he employs diverse models, including mammalian cell lines, the Drosophila model, and the Aedes albopictus vector. These models provide a robust framework for investigating the complex mechanisms at play in both hosts and vectors, offering valuable insights into the transmission and control of emerging infectious diseases.